Ranexa works by improving blood flow to help your heart work more efficiently. It is not for usage during an acute (or emergency) angina attack. Ranexa reduces the number of times you may experience chest pain.
Relieving symptoms of angina will increase your ability to exercise and perform strenuous work.
Ranexa (or Ranolazine) works differently than other medications for angina. Therefore, Ranexa can be used with other medicines for blood pressure control and heart problems. It can be taken with other angina medicines (including nitrates, beta-blockers such as metoprolol, calcium channel blockers such as amlodipine). Ranexa acts by improving how well your heart uses oxygen to do more work with less oxygen.
This medication is usually used with ACE inhibitors, calcium channel blockers, angiotensin receptor blockers, beta-blockers, or nitrates. This drug is usually available only with a doctor’s prescription. Ranexa is available in the following dosage forms- Tablet, Extended Release. It is unknown if Ranexa is safe and effective in children younger than 18 years.
How long does it take for Ranexa to start working?
Ranolazine (or Ranexa) does not work very fast and usually takes around 4 hours for peak effect. The apparent terminal half-life of Ranexa is about 7 hours. A steady-state is generally achieved within three days of twice-daily dosing with Ranexa.
Mechanism of action of Ranexa
Ranexa inhibits persistent or late inward sodium current in heart muscle in various voltage-gated sodium channels. Inhibiting that sodium current causes reductions in intracellular calcium levels. This, in turn, causes reduced tension in the heart wall, resulting in reduced oxygen requirements for the muscle.
Important information about Ranexa
Ranexa may help control your condition. However, it will not cure it. Continue to take Ranexa even if you feel well. Do not stop taking Ranexa abruptly without talking to the doctor. Don’t use Ranexa for a condition for which it wasn’t prescribed. Don’t give Ranexa to others, even if they have the same condition as yours. It can harm them.
Dosing information of Ranexa
Ranexa Dosage Forms And Strengths
Ranexa is supplied as film-coated, oblong-shaped, ER or extended-release tablets in the following strengths:
500 mg Ranexa tablets are light orange, with GSI500 on one side
1000 mg Ranexa tablets are pale yellow, with GSI1000 on one side
Ranexa 750 mg pale green oval-shaped tablet engraved with 750 on one side
The Ranexa 375 mg tablets are oval-shaped and pale blue and have engraving CVT375 or 375 on one side.
Usual Adult Dose of Ranexa for Angina (or Chest Pain): The typical starting Ranexa dose is 500 milligrams orally twice daily. If required, your doctor can increase it to 1000 milligrams orally twice daily. The maximum recommended daily Ranexa dose is 1000 milligrams twice daily. Buy Ranexa 500 mg online overnight from our trusted online pharmacy store.
Warning and precautions
Before you take Ranexa, tell the doctor if you:
Have a family history of a heart condition, known as ‘QT prolongation or long QT syndrome.’
Have or have ever had an abnormal electrocardiogram (ECG: a test that measures the electrical activity of your heart) or low levels of potassium in the blood
Have liver problems
Are allergic to Ranolazine, any other drugs, or any of the ingredients in Ranexa ER tablets.
Have kidney problems
Are planning a pregnancy, it isn’t known if Ranexa can harm your unborn baby.
Plan to breastfeed or are breastfeeding. Ranexa may pass into your breast milk. You and the doctor should decide if you should breastfeed.
Tell the doctor about all the medicines you take, including nonprescription and prescription drugs, vitamins, and herbal supplements. Ranexa can affect how other drugs work, and other medications may affect how Ranexa works.
How should I take Ranexa?
Take Ranexa precisely as the doctor tells you. Your doctor will tell you how much Ranexa to take and when to take it. Ranexa comes as an ER (long-acting) tablet to take by mouth. Ranexa is usually taken without or with food twice daily. Take Ranexa at around the same time each day. Follow the directions on your prescription label carefully, and ask the doctor to explain any part you do not understand. Don’t take less or more of it or take the drug more often than prescribed by the doctor. Swallow the Ranexa tablets whole; do not chew, break, or crush them before swallowing. You can buy Ranexa 750 mg online from our site because we offer all the medicines at the best prices.
The doctor shall start you on a low dosage of Ranexa and gradually increase your dosage of Ranexa. Do not take Ranexa to treat a sudden attack of angina. The doctor will tell you what you must do if you experience an episode of angina. Ensure that you understand these directions. Do not change your Ranexa dose unless your doctor tells you to.
Tell the doctor if you still experience symptoms of angina after starting Ranexa. Use this medicine regularly to get the most benefit from it. Ask the pharmacist for a copy of the manufacturer’s information for the patient. If you forget to take a dose of Ranexa, wait to take the next Ranexa dose at your regular time. Don’t make up for the missed dose.
Don’t take more than one Ranexa dose at a time. If you take too much Ranexa, call the doctor or immediately go to the nearest emergency room. Store Ranexa tablets at room temperature between 59Â° to 86Â°Farenheit (15Â° to 30Â°Celcius). Keep Ranexa out of the reach of children.
What should I avoid while taking Ranexa?
Grapefruit and grapefruit juice. Limit products that contain grapefruit in them. They may cause your blood levels of Ranexa to increase. Ranexa can cause lightheadedness, dizziness, or fainting.
If you experience these symptoms, do not drive a car, use heavy machinery or tools, or do anything that needs you to be alert.
What are the inactive and active ingredients in Ranexa?
Active ingredient: Ranolazine
Inactive ingredients: 500 mg Ranexa tablet: carnauba wax, methacrylic acid copolymer (Type C), hypromellose, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol, talc, polyethylene glycol, sodium hydroxide, titanium dioxide, Iron Oxide Yellow, and Iron Oxide Red
1000 mg tablet: carnauba wax, hypromellose, methacrylic acid copolymer (Type C), magnesium stearate, microcrystalline cellulose, sodium hydroxide, titanium dioxide, polyethylene glycol, lactose monohydrate, triacetin, and Iron Oxide Yellow
Side effects of Ranexa
Ranexa can cause severe side effects, such as:
Changes in the electrical activity of your heart known as QT prolongation- Your doctor can check the electrical activity of your heart with an ECG. Tell the doctor immediately if you feel lightheaded, faint, or irregular or fast heartbeat while taking Ranexa. These can be symptoms related to QT prolongation.
Kidney failure in people with severe kidney problems- Your doctor will need to do tests to check how your kidneys are working.
fast or pounding heartbeats,
fluttering in your chest,
painful or difficult urination,
little or no urination,
swelling in your feet or ankles,
shortness of breath, and
What is the working mechanism of Ranexa?
Ranexa has a unique mechanism of action, and as a result, it can be used with other drugs to treat angina to improve the symptoms. It was believed that this drug caused the heart muscle to switch from taking fatty acids to glucose to produce energy. This process can reduce the amount of oxygen your heart needs to function and can diminish ischemia.
Some researchers believe that Ranexa actually works to block the late inward sodium channel in the heart cells. This sodium channel increases the concentration inside cardiac cells and increases the contraction of muscle and energy usage of the heart muscle.
When it blocks the sodium channel, it improves the metabolism in ischemic heart cells, reduces damage to the heart muscle, and decreases angina symptoms. It is the commonly prescribed drug for angina symptoms in the USA.
It can be an addictive drug, so take it under the prescription-only. But, when you shop online, you can buy Ranexa online without a prescription.
Precautions while taking Ranexa
Before taking Ranexa, consult your health care provider if you are allergic to it or have any other allergies. This drug contains some inactive ingredients, which can result in a severe allergic reaction or fatal side effects. Talk to them for more details.
Before you use this drug, talk to your health care professional about medical history, especially if you have kidney or liver problems. This drug is not safe for people suffering from heart rhythm disorder or family history if it prolongs QT syndrome.
This drug can cause a severe condition that can affect the rhythm of the heart. This condition can rarely cause severe irregular heartbeat or other symptoms such as severe dizziness or fainting that need immediate medical attention. This risk of this condition increases if you have specific medical health issues or take drugs that may result in QT prolongation.
There is no evidence of how Ranexa affects pregnant women or breastfeeding mothers. It is unknown if this drug can pass into the breastmilk. So, when you buy Ranexa online, consult your health care professional about the risk and benefits of the medicines on you and your child.
How can I consume Ranexa?
Take Ranexa exactly as prescribed by your health care professional. Follow all the instructions on your medication guide properly. Your health care provider may change your dose gradually to ensure you get the best result. Do not take this drug in heavy doses or in a smaller amount and more than the prescribed time.
Doctors recommend taking Ranexa orally, usually twice a day with or without food and as directed by the health care provider. Swallow the pill as a whole without crushing, breaking, or chewing the medicine. Doing such activity can release all the medication at once and result in side effects. It can be addictive if taken for a prolonged time. So, take only under the prescription. But, when you shop online, you can buy Ranexa online without a prescription.
Avoid consuming grapefruit in any form while taking this medication. Grapefruit has the potential to increase the number of certain drugs in your bloodstream. Talk to your health care provider for more information.
This drug is available in the strength of Ranexa 375mg, 500 mg, 750 mg. Your health care provider will start your treatment at the lower possible dose and will gradually increase the amount to avoid any dependence on the medication.
The initial recommended dose of Ranexa is 500 mg twice a day. According to clinical symptoms, you can increase it to 1000 mg twice a day, as needed.
You can take it with or without food. But, do not increase the amount above 1000 mg twice a day.
If you missed a dose, skip that dose and take the next dose at a scheduled time. Never double the next dose.
What are the side effects of Ranexa?
Call for emergency help if you notice symptoms of an allergic reaction such as hive and swelling on the face, lips, and throat. It may give you some severe side effects such as:
headache with chest pain
Liver or kidney problems such as painful urination, swelling in ankles and feet, or shortness of breath.
Some common side effects may include:
headache or dizziness
constipation or nausea
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When you take Ranexa, avoid doing any hazardous activities that need your alertness until you know how it will affect your body. Doing such action can result in severe injuries and falls. Also, avoid consuming alcohol in any form while taking this drug; it may make you drowsy and dizzy and result in severe side effects.
Potent drugs such as Ranexa are approved for limited medical purposes and must be used together with necessary precautions. Taking it for a prolonged time may lead to psychological and physical dependence.
The more common side effects of Ranexa include headache, nausea, constipation, and dizziness. Call the doctor for medical advice regarding side effects.